IL4 and neoplasm: TAMs express M2 markers (i.e., CD163, CD206) and produce immunosuppressive cytokines, for example, IL-4, IL-10, transforming growth factor-β (TGF-β), and secretory factors such as matrix metalloproteinases (MMPs), epithelial growth factor (EGF), and vascular endothelial growth factor (VEGF) that support tumor invasiveness and angiogenesis [21].