Disruption of VEGF/VEGFR-2 signaling by simultaneous transfer of CAR T cells expressing anti-VEGFR-2 and T cells specific for gp100 (PMEL), TRP-1 (TYRP1), or TRP-2 (DCT) significantly eradicated B16 melanoma tumors in mice [86]. The gene discussed is VEGFA; the disease is melanoma.