Alzheimer's disease is characterized by an enanched expression levels of VDAC1 (Yoo et al., 2001; Cuadrado-Tejedor et al., 2011) and by reduced interaction of VDAC1 with the glycolityc enzymes HKs (Smilansky et al., 2015). The gene discussed is VDAC1; the disease is early-onset autosomal dominant Alzheimer disease.