Despite conflicting opinions about the essential role for VDAC and adenine nucleotide translocase (ANT) in permeability transition pore (PTP), a channel whose opening leads to mitochondrial depolarization, VDAC-ANT complex is still recognized as an anti-cancer target (Beutner et al., 1998; Neuzil et al., 2013; Figure 3A, Group 3). Here, VDAC1 is linked to cancer.