Besides, in cultured endothelial cells and vascular smooth muscle cells, hyperglycemia-induced activation of PKC can cause over-expression of plasminogen activator inhibitor-1 (PAI-1) and the activation of NF-κB (18).This could result in vascular damage via inflammation; increases the permeability of basement membrane thickening, angiogenesis and thrombotic vascular occlusion. The gene discussed is SERPINE1; the disease is Hyperglycemia.