Especially, the polymorphic variant of CHEK2 gene (1100delC) is associated with increased risk of breast, prostate, colorectal, and thyroid cancers (9, 10, 20), whereas the missense variant I157T, in addition to the above cancers, is known to increase the risk of kidney cancer, ovarian adenocarcinoma, and borderline ovarian cancers (16, 21). The gene discussed is CHEK2; the disease is cancer.