Because diabetes is a disease involving many metabolic pathways, prominent among which are damaged central insulin secretion and accompanying peripheral insulin resistance (Basevi, 2012), we constructed diabetes-related gene engineering mouse models containing either one transgene (CHOP), two transgenes (hIAPP and CHOP) or three transgenes (11β-HSD1,CHOP and hIAPP). The gene discussed is INS; the disease is Insulin resistance.