High-risk prostate cancers (with a Gleason score of at least 7) have been shown to be more accurately identified using the STHLM3 model, which suggests that structured screening that includes clinical factors, PSA and some PSA derivatives, and germline allelic variants, could reduce the number of prostate biopsies by about a third, when compared to PSA alone [11]. This evidence concerns the gene KLK3 and Familial prostate cancer.