YAP1 and cancer: For example, AREG, HBEGF, CCND1, and RRM2 stimulate cell proliferation; AURKA, BUB1, CEP55, KIF23, and ZWILCH participate in mitosis;68, 74 YAP cooperates with FOXM1 to promote chromosome instability59, and CXCL5 mediates communication between cancer cells and myeloid-derived suppressor cells47, which contributes to the immunosuppressive microenvironment characteristic of PDAC.