APOE and dementia: Risk factors classically related to CTE include the frequency of repeated exposure (i.e., career length, total number of fights, retirement age), technical supervision intensity, sparring increase, and apolipoprotein genotype (APOE).7 Dementia pugilistica has been included among the acquired tauopathies, but the pathophysiology of CTE is still under scrutiny, although it has been suggested that neuroinflammation can drive the association between tau hyperphosphorylation and dementia development following traumatic brain injury.8