AKT1 and myotonic dystrophy type 2: Likewise, 11 miRNAs, involving the muscle enriched miRNA miR-208, are downregulated in the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/AKT and in the transforming growth factor-β (TGF-β) signaling pathways of patient muscle samples affected by myotonic dystrophy type 2 (DM2) [100].