In children muscle affecting by dermatomyositis, it was observed that 33 miRNAs resulted elevated [97], miR-126 was significantly decreased in subjects in the first stage of pathology when related to control subjects [115] and it has been suggested to play a particular function in the first but not in the last stage of juvenile dermatomyositis by contributing to the expression of the vascular cell adhesion molecule 1 (VCAM-1), a protein usually demonstrated in the progression but not in the complete muscle fibers. This evidence concerns the gene VCAM1 and dermatomyositis.