RB1 and head and neck squamous cell carcinoma: Moreover, a recent study by Walline et al demonstrated that HPV-related HNSCC express a higher title of the oncoprotein p16 and a lower title of the oncoproteins pRB and p53, even though oncoprotein p53 could be mutant in some subsets of HPV-related HNSCC, usually more aggressive than those expressing a wild type p53 oncoprotein [87].