However, the TP53 p.Arg248Gln mutant has been associated with metastasis in mouse models [21] and shorter patient survival in an analysis of TCGA data for breast invasive carcinoma, colorectal cancer, glioblastoma, lung squamous cell carcinoma and ovarian serous cystadenocarcinoma [22]. Here, TP53 is linked to squamous cell lung carcinoma.