The median copy numbers of methylated TWIST1 were 0.0 (range, 0 to 11.4) in the control group, 1.9 (range, 0 to 11.2) in the non-advanced adenoma group, 1.7 (range, 0 to 26) in the advanced adenoma group, and 1.8 (range, 0 to 330) in the CRC group (Figure 4A). This evidence concerns the gene TWIST1 and adenoma.