FLT3 and neoplasm: In SCID/beige mice bearing MV-4-11 tumors (FLT3-ITD+) treated with SEL24-B489, we noted marked dose – dependent tumor reduction (67%, 74% and 82% tumor growth inhibition (TGI) for 50, 75 and 100 mg/kg daily doses, respectively) (Figure 4A).