This phaenomenon has previously been observed in vitro: phospho-ERK levels measured in melanoma cells treated with the BRAFi PLX4720 were completely recovered after 24h of treatment, even though cell growth arrest and apoptotic cell death were still present at later time points, as evidenced by annexin-V flow cytometry, MTT, and cell counting and it was interpreted as the early cell requirement to evade treatment [55]. The gene discussed is ANXA5; the disease is melanoma.