Thus, the higher CTLA-4 expression not only in Teff and Treg cells, but also in tumor cells, might facilitate tumor cellular lysis through an IPI-dependent cell-mediated cytoxicity by FcRγ expressing immune cells, such as monocytes for Treg [62] or natural killer and lymphocytes Tγδ for tumor cells [63]. This evidence concerns the gene ABCA1 and neoplasm.