We studied the immunohistochemical expression of ALCAM extracellular domain (non-cleaved protein) and a representative set of epithelial (E-cadherin/β-catenin major adhesion complex) and mesenchymal molecules involved in EEC dissemination (ETV5, COX-2, SNAIL, SLUG, MMP-2 and -9), in both the superficial and the invasive areas of the tumor. Here, ALCAM is linked to neoplasm.