Emerging evidence based on several preclinical mouse model studies also demonstrated the activation and importance of PI3K-mTOR signaling in a MYC-driven (Group 3) MB development [25–31], suggesting that PI3K-mTOR signaling not only plays a role in SHH-driven MB tumor progression, but also is equally important for MYC-driven MB development. The gene discussed is MYC; the disease is neoplasm.