To determine the single agent growth inhibitory effect of HH pathway inhibitor Vismodegib, PI3K-mTOR pathway dual inhibitor BEZ235 and chemotherapy cisplatin against HH/MYC-driven MB in vitro, the HH-derived MB cell line Daoy and three MYC-amplified MCL cell lines D-283, D-341 and HD-MB03 [37, 38] were incubated individually with Vismodegib (1-100 μM), BEZ235 (1-100 nM) and cisplatin (0.1-10 μM) in a dose-dependent manner for 72 hours, and the growth of the cells was assessed using MTT assays. The gene discussed is MYC; the disease is mantle cell lymphoma.