In this study, we explored the activation of JAK2/STAT3 pathway in serous HEY and clear cell carcinoma TOV21G cell lines in vitro by Western Blot and immunofluorescence in response to the concentration of paclitaxel which inhibited cell growth by 50% (GI50) (HEY: 0.05ng/mL, TOV21G: 0.01ng/mL). The gene discussed is STAT3; the disease is clear cell adenocarcinoma.