Forced expression of a 17 kDa MUC16-Cter fragment in pancreatic cancer cells mediated nuclear translocation of JAK2 which preferentially phosphorylated tyrosine 41 of histone H3 (H3Y41) in a STAT-independent manner and up regulated stemness specific genes LMO2 [45, 46] and NANOG [46, 47]. Here, LMO2 is linked to familial pancreatic carcinoma.