PPARGC1A and Sepsis: Similarly, mRNA expression of PGC-1α (COX3: r = 0.543, P = 0.0109; ND1: r = 0.5992, P = 0.0041), and NDUFB8 (COX3: r = 0.549, P = 0.0100; ND1: r = 0.517, P = 0.0165) was reduced after sepsis-induced AKI, and their expression was also inversely associated with UmtDNA levels (Figure 7).