CYCS and B-cell chronic lymphocytic leukemia: Acacetin (4′-methoxy-5,7-dihydroxyflavone), a natural flavone, can selectively induce apoptosis in CLL cells by directly targeting mitochondria through increased ROS production, loss of MMP, mitochondrial permeability transition pore, release of cytochrome c, and caspase 3 activation, while non-CLL lymphocytes remain unaffected [47].