To our knowledge, the present study is the first study to show that traditional Chinese medicine, GBE, could protect against diabetic myocardial injury, particularly apoptosis, myocardial fibrosis, and NF-κB-mediated inflammation via inhibition of ERS-related apoptosis, as evidenced by the decrease in p-JNK, caspase-12, and cleaved caspase-3 expression. Here, MAPK8 is linked to Myocardial fibrosis.