Upregulation of NF-κB expression leads to increased production of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6, which contribute to cardiomyocyte apoptosis and myocardial fibrosis [7]. This evidence concerns the gene NFKB1 and Myocardial fibrosis.