We recently defined the methylation profiles of the neuropeptide genes somatostatin (SST), tachykinin precursor 1 (TAC1), and galanin (GAL) and their cognate receptor gene members in HNSCC tumors [9–11]; however, further studies were required because of the small sample size and the lack of discrimination between the sites of origin of primary tumors. Here, SST is linked to head and neck squamous cell carcinoma.