We recently defined the methylation profiles of the neuropeptide genes somatostatin (SST), tachykinin precursor 1 (TAC1), and galanin (GAL) and their cognate receptor gene members in HNSCC tumors [9–11]; however, further studies were required because of the small sample size and the lack of discrimination between the sites of origin of primary tumors. The gene discussed is NPS; the disease is head and neck squamous cell carcinoma.