AKT1 and breast cancer: Zhang et al. showed that shikonin decreases tamoxifen resistance by inducing uc.57 in MCF-7R breast cancer cells that inhibits PI3K/Akt and MAPK signaling pathways through downregulating BCL11A [148]. In vivo pharmacokinetics studies represented shikonin as lower toxic [222], and this compound has potential to be considered further for the drug studies against breast cancer.