Several studies also represented that resveratrol binds with some important molecular targets of breast cancer pathway, including estrogen receptor-β (ERβ), cyclooxygenase-2 (COX-2), quinine reductase 2 (NQO2), inhibitor of kappa B kinase (IKK), and glutathione sulfotransferase (GSTP1), where COX-2 is involved in carcinogenesis/inflammation; ERβ and IKK are involved in gene modulations and transcriptional regulation; NQO2 and GSTP1 are phase II detoxification enzymes [158]. The gene discussed is ESR2; the disease is breast cancer.