LDHA and breast cancer: It appeared from the study by Li et al. [142] that treatment of SFN in human breast cancer cell lines decreased the number and size of mammospheres as well as ALDH+ cell population, while, in NOD/SCID xenograft model, daily treatment of sulforaphane at dose of 50 mg/kg for 2 weeks decreased ALDH+ and downregulated the Wnt/β-catenin self-renewal pathways.