Hypoxia and HIF signaling pathway have been shown to contribute to the regulation and sustenance of CSCs and EMT phenotype such as cell migration, invasion, and angiogenesis [115], via the increased expression of VEGF, IL-6, and CSC signature genes such as Nanog, Oct4, and EZH2, in pancreatic cancer for example [116]. Here, EZH2 is linked to pancreatic neoplasm.