These include CSC markers (ALDH [203], CD44 [204, 205], CD133 [206], EpCAM [207], and HER2 [208]), CSC niche interaction (TAM [209]), tumor microenvironment (immune cells/myeloid-derived suppressor cells), cytokines (IL1 [210], IL6 [211], and IL8 [212]), and immune checkpoint (CTLA-4 [213] or PD1/PDL1 [214]). Here, PROM1 is linked to neoplasm.