It has been indicated that besides cell autonomous resistance of CSCs, chemotherapy preferentially targets non-CSCs by the stimulation of cancer-associated fibroblasts (CAFs) which creates a chemoresistant niche by increased secretion of specific cytokines and chemokines, including interleukin-17A (IL-17A), a CSC maintenance factor by promoting self-renewal and invasion [120]. Here, IL17A is linked to cancer.