Another signaling pathway such as WNT, TGFβ, PI3K/Akt, EGFR, and JAK/STAT, as well as transcriptional regulators including OCT4, Nanog, YAP/TAZ, and Myc are also commonly activated in various cancer stem cells to regulate their self-renewal and differentiation state [21, 158]. Here, AKT1 is linked to cancer.