Last but not least, chemotherapy such as oxaliplatin induces Notch-1 receptor and its downstream target Hes-1 activity by increasing gamma-secretase activity in colon cancer cells; hence, inhibition of Notch-1 signaling by gamma-secretase inhibitors (GSIs) sensitizes colon cancer cells to chemotherapy [168]. This evidence concerns the gene HES1 and malignant colon neoplasm.