Furthermore, another PcG member EZH2, a catalytic subunit of polycomb repressor complex 2 (PRC2) which trimethylates histone H3 at lysine 27 (H3K27me) and elicits gene silencing, also participates in pancreatic cancer chemoresistance by silencing p27 tumor suppressor gene via methylation of histone H3-lysine 27 (H3K27) [141]. Here, EZH2 is linked to familial pancreatic carcinoma.