Finally, we observed that resveratrol specifically decreases the CD49f-positive subpopulation and speculate that this effect is through regulation of specific cancer stem cell pathways, such as shown in 2013 by Sato et al., who found that resveratrol reduces the self-renewal and tumor-initiating capacity of patient-derived glioma stem cells [39]. Here, ITGA6 is linked to central nervous system cancer.