The results of the colorimetric total cholesterol analysis showed that silencing ABCA1 significantly suppressed the inhibitory effect of TSF on PA-induced total cholesterol levels in mTECs without altering protein and mRNA expression levels of PGC-1α and LXR (Figure 6), revealing that the TSF might act as protection via the ABCA1-dependent mechanism to improve renal cholesterol efflux in DN. Here, PPARGC1A is linked to liver dysplastic nodule.