TNFRSF12A and essential hypertension: Calca is associated with Parkinson diseases (Buervenich et al., 2001) and essential hypertension (Luo et al., 2008), while Tnfrsf12a is an important molecule in cardiac hypertrophy disease (Ma et al., 2016), cardiac shock (Wang W. et al., 2016) retinal inflammation (Abcouwer et al., 2013), and atherosclerosis-related diseases (Munoz-Garcia et al., 2006, 2011; Moreno et al., 2013; Fernandez-Laso et al., 2017).