The most related top 10 canonical signaling pathways in turn in heart were atherosclerosis signaling, granulocyte adhesion and diapedesis, agranulocyte adhesion and diapedesis, HMGB1 signaling, aryl hydrocarbon receptor signaling, role of JAK1 and JAK3 in γc cytokine signaling, xenobiotic metabolism signaling, acute phase response signaling, fatty acid α-oxidation and IL-17 signaling. This evidence concerns the gene JAK3 and atherosclerosis.