F2 and rheumatoid arthritis: The most impacted top 10 canonical signaling pathways with a descending order in brain were catecholamine biosynthesis, role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis, gas signaling, role of osteoblasts, osteoclasts and chondrocytes in rheumatoid arthritis, atherosclerosis signaling, intrinsic prothrombin activation pathway, cAMP-mediated signaling, G-protein coupled receptor signaling, PCP pathway and eicosanoid signaling.