The common mechanisms shared in both are linked with atherosclerosis signaling and inflammatory response with at least the following target genes: Tnfrsf12a, Pla2g2f, Il1f9, Col1a1, Col1a2, and Col3a1 in brain, while Tnfrsf12a, SELP, SELE, IL6, and IL1A in myocardium. The gene discussed is COL1A1; the disease is atherosclerosis.