On the other hand, Tnfrsf12a expression in brain is regarded as a prognostic/predictive biomarker of brain metastasis (Martinez-Aranda et al., 2015), and protects neurodegeneration (Potrovita et al., 2004) and cerebral ischemia (Zhang et al., 2007). This evidence concerns the gene TNFRSF12A and Cerebral ischemia.