Ten key regulated genes (including Pla2g2f, Il1f9, Col1a1, Col1a2, and Col3a1 in the brain, while SELP, SELE, IL6, and IL1A in the myocardium, and Tnfrsf12a in both) are correlative with atherosclerosis signaling and inflammatory response. The gene discussed is TNFRSF12A; the disease is atherosclerosis.