PLAT and brain edema: By assessment of neurological function deficits, infarct volume, cerebral edema, cerebral hemorrhage and expression of apoptotic gene, we found that combination of t-PA (2.5 mg/kg) plus DHI (4 mL/kg) which treated at 4.5 h after stroke significantly improved neurological function recovery, reduced infarct volumes, cerebral edema, inhibited the expression of proapoptotic genes, and enhanced that of inhibiting-apoptotic genes as compared the other combination groups of delayed treatment.