The combination of DHI (4 mL/kg) plus t-PA (2.5 mg/kg) showed the smallest Brain edema, followed the combination of t-PA (1.25 mg/kg) plus DHI (2 mL/kg) and the combination of t-PA (5 mg/kg) plus DHI (8 mL/kg), when compared with the model group (Figure 1D). This evidence concerns the gene PLAT and brain edema.