Recovery of cholinergic function with AChE inhibitors, including donepezil, tacrine, pyridostigmine, galantamine, rivastigmine and Huperzine A shows potential disease-modifying benefits in the treatment of neuropsychiatric symptoms in patients with AD (Linton, 2005; Rafii et al., 2011) and dementia (Freund-Levi et al., 2014), as well as for the musical hallucinations that occur with hearing loss (Ukai et al., 2007; Zilles et al., 2012; Blom et al., 2014, 2015) or hearing loss with tinnitus (Strauss and Gertz, 2009). This evidence concerns the gene ACHE and Tinnitus.