The recovery of lost cholinergic innervation or function by the cholinesterase inhibitor donepezil or Huperzine A could alleviate tau pathology as well as age- and AD-related chronic neuroinflammation (Yoshiyama et al., 2015), and D-galactose-induced neurovascular damage (Ruan et al., 2014d). Here, MAPT is linked to Alzheimer disease.