SNCA and Parkinson disease: The pathological hallmarks of PD are the presence of intracellular inclusions, called Lewy bodies (LB) in the survival dopaminergic neurons (Dauer and Przedborski, 2003; Olanow et al., 2009; Tolleson and Fang, 2013; Dickson, 2018), which are mainly composed by a mixture of substances including alpha-synuclein, ubiquitin, neurofilament proteins and iron (Castellani et al., 2000; Goedert, 2001; Mandel et al., 2004; Fares et al., 2016).