Our lab and others have previously demonstrated chemokine/receptor expression (CX3CL1/CX3CR1; CXCL12/CXCR4; Yuridullah et al., 2006; Vera et al., 2008; Arms et al., 2010, 2013; Gonzalez et al., 2014a) and function and referred somatic sensitivity (CXCL12/CXCR4; CCL2/CCR2; Tanaka et al., 2004; White et al., 2005a,b; Dansereau et al., 2008; Gosselin et al., 2008; Arms et al., 2010, 2013; Gonzalez et al., 2014a) associated with urinary bladder inflammation induced by cyclophosphamide (CYP) in rodents. This evidence concerns the gene CXCR4 and cystitis.