In the present study using male and female C57BL/6 mice with CYP-induced cystitis (4 h, 48 h, chronic), we extend these observations and examine: (1) CXC chemokines (CXCL9-11) mRNA and protein expression in the urinary bladder (urothelium, detrusor smooth muscle); (2) effects of CXCR3 receptor blockade on urinary bladder function and somatic sensitivity (hindpaw and pelvis) using conscious cystometry and von Frey filament testing, respectively; and (3) mRNA and protein expression of CXCR3 in the urinary bladder. The gene discussed is CXCR3; the disease is chronic cystitis.