The current studies extend these reports by: evaluating CXC chemokines in male and female mice with several CYP treatment durations (4 h, 48 h, chronic), evaluating CXCR3 receptor blockade on bladder function and somatic sensitivity in mice with CYP-induced cystitis, and determining CXCR3 receptor expression in the urinary bladder. This evidence concerns the gene PPIG and cystitis.