Although CXC chemokines did not demonstrate regulation in the urinary bladder with cystitis in male mice and male mice were not evaluated in the current functional studies, regulation at the level of the CXCR3 receptor with cystitis may be present and affect CXC/CXCR3 signaling in micturition pathways in the absence of changes in CXC chemokine expression in male mice. This evidence concerns the gene CXCR3 and cystitis.