The current studies demonstrate increased expression of CXC chemokines (CXCL9, CXCL10) in the urinary bladder with CYP-induced cystitis (4 h) and improved functional changes in the urinary bladder and somatic sensation (pelvic and hindpaw) with CYP-induced cystitis (4 h and 48 h) following CXCR3 receptor blockade in female mice. This evidence concerns the gene CXCL9 and cystitis.