Here, we show that ATF3, a transcription factor that is induced by a variety of stress signals including myocardial ischemia (Okamoto et al., 2001), chemical toxicity of the liver (Chen et al., 1996) and renal ischemia-reperfusion (Li et al., 2010), down-regulates the expression of AChE, another stress-induced protein. The gene discussed is ACHE; the disease is myocardial ischemia.