Concerning FASTKD2 (FAST kinase domain-containing protein 2, mitochondrial), it was shown to be regulated by NRIF3 (nuclear receptor-interacting factor 3) and the DIF-1 (interferon regulatory factor 2-binding protein 2) complex and this regulation modulated apoptosis in mammary and pancreatic cancer cells [33, 34]. The gene discussed is ITGB3BP; the disease is familial pancreatic carcinoma.