Outlined in Figures 5 and 6, when stratified by median insulin (6.83 mU/L) and median amylin (6.75 pM), individuals with AD presented with lower cRAGE (p = 0.04, 0.03) and cRAGE : esRAGE (p = 0.01, 0.01). Here, IAPP is linked to Alzheimer disease.