To better characterize the effects of metabolic factors on sRAGE pathophysiology in AD, all participants were stratified by the following factors: T2DM diagnosis, FGS as determined by ADA criteria, obesity by BMI according to the WHO, median insulin, median amylin, median HOMA-IR, and median fat mass. This evidence concerns the gene IAPP and obesity due to melanocortin 4 receptor deficiency.