Despite the absence of syndromic features, germline mutations in SDHB and FLCN are not uncommon in such cases and molecular genetic testing for an RCC gene panel [e.g. FLCN, FH, MET, SDHB, VHL (± BAP1)] and cytogenetic analysis is generally performed in suspected cases. The gene discussed is FLCN; the disease is renal cell carcinoma.