In this regard, our findings and those of Andrade et al. (23) indicate that most of the odontogenic tumors present variations among RANK-L and OPG expression, possibly dependent on the type of tumor, mechanisms of growth, and size, which has been interpreted as active and inactive stages of tumor growth and stages of interference with tumor osteolysis (19). The gene discussed is TNFSF11; the disease is odontogenic neoplasm.