Our study demonstrates that m-TRβ1 expression in SK-hep1 cells decreases cancer cell proliferation, impedes tumor cell migration, and inhibits tumor growth in vivo by up-regulating Caspase-3, 4-1BB, and Bak expression, increasing Caspase-3 activity, and down-regulating Bcl-2 expression. This evidence concerns the gene CASP3 and neoplasm.