LEPR and obesity due to melanocortin 4 receptor deficiency: To our knowledge this is the first study trying to establish an association between clinical, metabolic phenotypes and LEPR rs11371101, MC4R rs2229616 and rs17782313 and PPARG-2 rs1801282 in Portuguese children and the first association between biochemical parameters dependent from obesity and FTO rs9939609 in the same population.