The aim of the present study was to assess the independent contributions of LEPR (rs1137101), FTO (rs9939609), MC4R (rs2229616 and rs17782313), and PPARG-2 (rs1801282) polymorphisms for clinically overweight or obesity phenotypes and endocrine-metabolic traits in prepubertal children. This evidence concerns the gene MC4R and obesity due to melanocortin 4 receptor deficiency.