In most cell types, the human VRK1 gene is expressed at different levels and is not mutated in cancer, and it is overexpressed in many cancer types of different origins correlating with a poorer prognosis in breast [116, 117], lung [115], liver [118], glioblastoma [119], head and neck [110], and esophageal cancer [120]. Here, VRK1 is linked to cancer.