Upregulated IQGAP1 levels which lead to an increase in active Cdc42 pools are associated with enhanced tumor proliferation, invasion and angiogenesis15, while overexpression of a dominant-negative IQGAP1 reduced GTP-bound Cdc42 and neoplastic transformation of human breast cancer epithelial cells15. This evidence concerns the gene IQGAP1 and breast carcinoma.