Additionally, in mice uniformly sacrificed at 2 months of age, 10–15% of the Hoxa9,10,11−/− Hoxc9,10,11+/−, and Hoxa9,10,11+/− Hoxc9,10,11−/−, and triple heterozygote Hoxa9,10,11+/− Hoxc9,10,11+/− Hoxd9,10,11+/− mice showed grossly cystic kidneys (Fig. 2c,X’,Y’). This evidence concerns the gene HOXD9 and Renal cyst.