Although, neither IGF2BP1 nor IGF2BP3 interacts with PRMT5 (Supplementary Fig. 13k), IGF2BP1 and IGF2BP3 regulated the protein level of PRMT5 by stabilizing LINC01138 in the HCC cells (Fig. 7e), suggesting the existence of the IGF2BP1/IGF2BP3-LINC01138-PRMT5 flow in the HCC cells. This evidence concerns the gene LINC01138 and hepatocellular carcinoma.