Moreover, following treatment with a protein-synthesis inhibitor cycloheximide (CHX), LINC01138 knockout decreased the half-life of the PRMT5 protein, whereas LINC01138 activation increased the half-life of the PRMT5 protein in the HCC cells (Fig. 4b and Supplementary Fig. 8f), with β-actin as the relative control (Supplementary Fig. 8g). This evidence concerns the gene LINC01138 and hepatocellular carcinoma.