In which, we revealed AQP3, AQP9, and AQP11 mRNA expression were associated with improved OS in all gastric cancer patients especially with intestinal subtypes, whereas AQP0, AQP1, AQP4, AQP5, AQP6/2L AQP8, and AQP10 mRNA expression were associated with poor OS in all gastric cancer patients. The gene discussed is AQP4; the disease is gastric cancer.