Future studies involving state-of-the-art in vivo measurements of gluconeogenesis [71] and investigation of insulin sensitivity using hyperinsulinemic, euglycemic clamp studies in juvenile and sexually mature GHR-KO and control pigs will help to clarify the relative contributions of these mechanisms to juvenile hypoglycemia in LS and its normalization in adult LS patients. This evidence concerns the gene GHR and Hypoglycemia.