In addition, individuals with certain rare genetic syndromes, such as Peutz-Jeghers (caused by STK11 mutations, where the risk of BC is 45% by the age of 70) or Li-Fraumeni (caused by TP53 mutations, with a BC relative risk of 6.4×), have an increased risk of breast cancer [9, 10]. Here, STK11 is linked to breast cancer.