H2AX and breast carcinoma: For the H2AFX polymorphisms, the logistic regression analysis revealed that the rs7759 GG and rs8551 TT were significantly increased among breast cancer patients compared to the rs7759 AA and rs8551 CC genotypes, respectively (rs7759 GG versus AG: adjusted OR = 1.94, 95% CI 1.14 to 3.28; P = 0.042, after Benjamini-Hochberg correction; rs8551 CC versus TT, OR = 1.82, 95% CI 1.18 to 2.80; P = 0.034, after Benjamini-Hochberg correction).