The possible mechanism of the interaction may included that: 1 continuous hypertension causes glomeruli high pressure, and makes the glomerular filtration rate and urine β2- microglobulin increase; 2 low level blood lead alone does damage to renal tubular epithelial cells, restrains ATP activity, and leads to tubular reabsorption dysfunction [18]. This evidence concerns the gene HLA-G and hypertensive disorder.