Outside of the nucleus, TNPO1 colocalizes with some cytoplasmic RNA granules, where it coexists with FUS, purine-rich element binding protein A (Pur-α, which modulates toxicity of ALS-associated FUS mutants), and Staufen-1 (a marker of neuronal transport granules) (Jain et al., 2016). The gene discussed is FUS; the disease is amyotrophic lateral sclerosis.