F2R and breast carcinoma: Platelet releasates, induced by the agonists of the thrombin receptors, protease activated receptor-1 (PAR1) and PAR4 [37], promote the proliferation of MCF-7 and MDA-MB-231 breast cancer cells and angiogenesis via the phosphoinositide 3-kinase/protein kinase C (PI3K/PKC) pathway [38].