Age-related up-regulated DEGs important in cell proliferation, migration and apoptosis include C-X-C Motif Chemokine Ligand 14 (Cxcl14) [55], and Protein Tyrosine Phosphatase, Receptor Type Q (Ptprq) [56], which is increased in renal injury [57] Taken together, both down- and up-regulated genes in aged CoRL was consistent with a decline in stemness, migration, proliferation, and an increase in apoptosis, supporting the notion that with advancing age, their pluripotent stemness decreases. This evidence concerns the gene PTPRQ and injury.