ICAM1 and clear cell renal carcinoma: As an immunoglobulin supergene family member, ICAM1 is shown to be critically involved in adhesion of cancer cells to ECM [36], in particular, overexpression of ICAM1 correlates with increased tumor malignancy and poor outcome in lung cancer [37], clear cell renal cell carcinoma [38], and mouse GBM model [39].