Of the 44 genes identified, 23 genes (e.g., IL6, IL8, TIMP1, CCR5, SREPINE1, and SREPING1) have been reported to be involved in GBM pathogenesis or significant in predicting overall survival, indicating that our big data-based analysis using TCGA and CGGA cohorts has prognostic values. The gene discussed is IL6; the disease is glioblastoma.